CNS Involvement by North American-Adult T-cell Leukemia/Lymphoma Is Associated With Discrete Dissemination Patterns and Molecular Profiles, Involving XPO1 E571 and KLF2/PI3KCD in Selected Cases.

doi:10.1200/PO.23.00526

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Article

CNS Involvement by North American-Adult T-cell Leukemia/Lymphoma Is Associated With Discrete Dissemination Patterns and Molecular Profiles, Involving XPO1 E571 and KLF2/PI3KCD in Selected Cases.

JCO precision oncology - 1 Jul 2025

Shah Nishi, Suchanek Melissa, Thakkar Astha, Patel Riya Jayesh, Rahman Shafia, Acuna-Villaorduna Ana, Shah Urvi, Adrianzen Herrera Diego, Slasky Shira, Gritsman Kira, Goldfinger Mendel, Shastri Aditi, Mantzaris Ioannis, Kornblum Noah, Bachier-Rodriguez Lizamarie, Feldman Eric, Cooper Dennis, McNeill Katharine Anne, Wang Yanhua, Shi Yang, Verma Amit, Ye B Hilda, Janakiram Murali, Sica R Alejandro

Abstract excerpt

PURPOSE: CNS involvement in North American adult T-cell leukemia/lymphoma (NA-ATLL) remains poorly understood. This study examined the CNS involvement in patients with ATLL treated at a tertiary hospital in New York City. METHODS: CNS involvement was defined by positive cerebrospinal fluid (CSF) cytology, flow cytometry, positive CNS imaging, or neurological examination findings. RESULTS: Among 94 patients with...

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PMID: 40712110
DOI: 10.1200/PO.23.00526
PMCID: PMC12309975

Genes

XPO1
KLF2

Variants

Provenance

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