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Article

Exogenous melatonin alleviates premature ovarian failure by regulating granulosa cell autophagy

23 Jul 2025

Abstract excerpt

Premature ovarian failure (POF) is a disease closely related to the apoptosis of granulosa cells (GCs) in the follicle. In this study, exogenous melatonin (Mel) was used to interfere with POF model mice, so as to provide reference for Mel prevention and treatment of POF. Mel could promote estrogen secretion and improve ovarian physiological function in mice. In GCs, mitochondrial membrane potential increases and...

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PMID: 40701990
DOI: 10.1038/s41536-025-00422-1

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