Article
Clinical diagnosis and typing of systemic amyloidosis in subcutaneous fat aspirates by mass spectrometry-based proteomics.
Haematologica - 1 Jul 2014
Vrana Julie A, Theis Jason D, Dasari Surendra, Mereuta Oana M, Dispenzieri Angela, Zeldenrust Steven R, Gertz Morie A, Kurtin Paul J, Grogg Karen L, Dogan Ahmet
Abstract excerpt
Examination of abdominal subcutaneous fat aspirates is a practical, sensitive and specific method for the diagnosis of systemic amyloidosis. Here we describe the development and implementation of a clinical assay using mass spectrometry-based proteomics to type amyloidosis in subcutaneous fat aspirates. First, we validated the assay comparing amyloid-positive (n=43) and -negative (n=26) subcutaneous fat...
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