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Hypertension Is Associated With Earlier Onset of Nontraumatic Subarachnoid Hemorrhage in Women: A Mendelian Randomization Study.

Stroke - 1 Oct 2025

Vanent Kevin N, Leslie-Mazwi Thabele M, Matouk Charles C, Sheth Kevin N, Levitt Michael R, Falcone Guido J

Abstract excerpt

BACKGROUND: Nontraumatic subarachnoid hemorrhage (SAH) is linked to hypertension, a condition highly influenced by common genetic variants. For complex diseases affected by genetic and environmental factors, genetic predisposition plays a key role in early onset. We hypothesize that elevated polygenic susceptibility to hypertension is associated with a younger age of onset in SAH. METHODS: We performed a...

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PMID: 40698383
DOI: 10.1161/STROKEAHA.124.047631

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