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Tumor-associated bacteria activate PRDX1-driven glycolysis to promote immune evasion and PD-1 antibody resistance in hepatocellular carcinoma

7 Jul 2025

Abstract excerpt

Background Recent studies have highlighted the presence of intratumoral bacteria in hepatocellular carcinoma (HCC), yet their contribution to immunotherapy resistance remains largely unexplored. This study investigates the mechanisms by which bacterial infection reshapes tumor metabolism to undermine the efficacy of anti-PD-1 therapy. Methods We conducted 16S rRNA gene sequencing on 29 HCC clinical samples and...

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PMID: 40693141
DOI: 10.3389/fmicb.2025.1599691

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