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Patient-derived pancreatic tumor bacteria exhibit oncogenic properties and are recognized by MAIT cells in tumor spheroids

22 Apr 2025

Abstract excerpt

Introduction Tumor-residing microbiota poses a new challenge in cancer progression and therapy; however, the functional behavior of patient tumor-derived microbes remains poorly understood. We previously reported the presence of tumor microbiota in intraductal papillary mucinous neoplasms (IPMNs), which are precursors of pancreatic cancer. Methods We examined the metabolic and pathogenic potential of clinical...

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PMID: 40330456
DOI: 10.3389/fimmu.2025.1553034

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