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Article

OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation

18 Jul 2025

Abstract excerpt

Ulcerative colitis (UC) develops through a complicated interaction between the host and microbiota. Intestinal fibroblasts are believed to play crucial roles in the pathogenesis of UC, but the influence of the host-microbiota interaction on the pathophysiology of intestinal fibroblasts remains poorly understood. Here, we demonstrate that OTU deubiquitinase 3 (OTUD3) suppresses pathologic activation of fibroblasts...

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PMID: 40680146
DOI: 10.1126/sciimmunol.adm6843

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