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Article

A pharmacological and brain imaging study of human vasopressin AVP1BR receptor functional polymorphisms.

BMC neuroscience - 17 Jul 2025

Alacreu-Crespo Adrián, Olié Emilie, Manière Maxime, Deverdun Jeremy, Lebars Emmanuelle, Corbani Maithé, Guillon Gilles, Courtet Philippe

Abstract excerpt

In humans, vasopressin AVP1BR receptor (hV1B) plays key roles in hypothalamic-pituitary-adrenal (HPA) axis regulation and social behavior. Three hV1B polymorphisms, rs35369693 (K65N), rs28632197 (R364H) and rs33990840 (G191R), have been related to psychiatric disorders with altered HPA axis function and social behavior. The aim of this study was to explore hV1B pharmacological properties as a function of the...

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PMID: 40676548
DOI: 10.1186/s12868-025-00963-7
PMCID: PMC12273463

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