Article
Phenomapping for novel classification of heart failure with preserved ejection fraction.
Circulation - 20 Jan 2015
Shah Sanjiv J, Katz Daniel H, Selvaraj Senthil, Burke Michael A, Yancy Clyde W, Gheorghiade Mihai, Bonow Robert O, Huang Chiang-Ching, Deo Rahul C
Abstract excerpt
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome in need of improved phenotypic classification. We sought to evaluate whether unbiased clustering analysis using dense phenotypic data (phenomapping) could identify phenotypically distinct HFpEF categories. METHODS AND RESULTS: We prospectively studied 397 patients with HFpEF and performed detailed clinical,...
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