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Article

Novel mutations of SRPX facilitate the stemness and malignant progression of glioma.

British journal of cancer - 1 Oct 2025

Tang Siyuan, Qu Chunhui, Zhang Mingyu, Zhou Peijun, Peng Xingzhi, Zhou Zhuan, Shen Liangfang, Yang Lifang

Abstract excerpt

BACKGROUND: Explorations of genomic profiles are of great clinical significance for glioma due to the high tumor heterogeneity and stemness. High-depth sequencing enabled to identify driver genes and potential treatment targets in glioma. METHODS: A whole exome sequencing analysis of 27 Chinese patients was conducted and somatic mutation signatures were analyzed using validated computational methods. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40665012
DOI: 10.1038/s41416-025-03091-5
PMCID: PMC12449449

Genes

AHR
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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