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Human adipose-derived stem cell exosomes reduce mitochondrial DNA common deletion through PINK1/Parkin-mediated mitophagy to improve skin photoaging

15 Jul 2025

Abstract excerpt

BACKGROUD: Mitochondrial DNA (mtDNA) deletion and oxidative stress are key contributors to skin photoaging. Mitophagy helps mitigate oxidative stress. Human adipose-derived stem cell exosomes (hADSC-Exos) have been shown to counteract skin photoaging. This study aimed to explore the role and mechanism of hADSC-Exos in addressing skin photoaging. METHODS: hADSC-Exos were isolated, and their surface markers were...

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PMID: 40660391
DOI: 10.1186/s13287-025-04475-3

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