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Leveraging Genomic Data to Examine the Causal Impact of Alcohol, Tobacco, Cannabis, and Opioid Use on Biological and Cognitive Ageing.

Addiction biology - 1 Jul 2025

Balbona Jared V, Jeffries Paul, Gorelik Aaron J, Nelson Elliot C, Bogdan Ryan, Agrawal Arpana, Johnson Emma C

Abstract excerpt

Although substance use is associated with a shortened lifespan, impeded health and accelerated biological ageing, the factors contributing to the associations between substance use and ageing are poorly understood. We used summary statistics from genome-wide association studies (GWAS) to investigate whether substance involvement (N from 28K to 2M)-including alcohol, tobacco, cannabis and opioid use and use...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40653731
DOI: 10.1111/adb.70066
PMCID: PMC12256578

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