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TRIM21‐Mediated K11‐Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma

13 Jul 2025

Abstract excerpt

Inhibitor of DNA binding 1 (ID1) is a key transcriptional regulator involved in the development of various cancers, including esophageal squamous cell carcinoma (ESCC). However, the mechanisms regulating ID1 ubiquitination in ESCC are not well understood. This study identifies TRIM21 as a novel E3 ubiquitin ligase that targets ID1 for K11-linked ubiquitination at lysine 91. Unlike typical ubiquitination that...

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PMID: 40652518
DOI: 10.1002/advs.202502501

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TRIM21‐Mediated K11‐Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell CarcinomaPMID 40652518Read ↗

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