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Article

Predictive biomarkers for immune checkpoint inhibition for patients with colorectal cancer: a comprehensive review.

Immunotherapy - 1 Jul 2025

Sahin Ibrahim Halil, Saridogan Turcin, Kim Richard

Abstract excerpt

Immune checkpoint inhibitors have resulted in treatment paradigm changes for the management of patients with solid tumors, including microsatellite instability-high (MSI-H) colorectal cancer (CRC). Although the benefit of these agents appears to be limited for microsatellite stable (MSS) CRC, recent studies suggest that the immune microenvironment of the early-stage MSS CRC and perhaps those with advanced-stage...

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Identifiers

PMID: 40652318
DOI: 10.1080/1750743X.2025.2530853
PMCID: PMC12355713

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POLD1
POLE

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