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Article

Effects of aging on gene expression networks in the Drosophila genetic reference panel.

Cell reports - 22 Jul 2025

Tan Suxu, Carbone Mary Anna, Zhou Shanshan, Morozova Tatiana, Arya Gunjan, Zhang Fei, Anholt Robert R H, Huang Wen, Mackay Trudy F C

Abstract excerpt

The genetic basis of naturally occurring variation in organismal senescence and lifespan remains largely unknown. We quantified genome-wide gene expression levels of young and 3-week-old flies of the Drosophila Genetic Reference Panel and performed a systems genetics analysis integrating genomic, transcriptomic, and organismal phenotype variation. Aging had widespread but small effects on nearly the entire...

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Identifiers

PMID: 40650906
DOI: 10.1016/j.celrep.2025.115999
PMCID: PMC12573664

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