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Article

Cumulative genetic effects of HPA axis on social phobia scrutiny fear: psychoticism and social face as mediators.

Anxiety, stress, and coping - 1 Jan 2026

Yang Yuting, Liang Wenting, Zhao Wenping, Lan Qi, Zhou Mingzhu, Gong Pingyuan

Abstract excerpt

BACKGROUND: Social phobia scrutiny fear is a stress response triggered by perceptions of social evaluation. However, the role of genetic polymorphisms in the Hypothalamic Pituitary Adrenal (HPA) axis in shaping this fear is not well understood. This study investigates how the cumulative genetic score of the HPA axis influences social phobia scrutiny fear. METHOD: Two independent samples were used. The first...

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PMID: 40639818
DOI: 10.1080/10615806.2025.2530702

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