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Article

A two-sample study on the relationship between polygenic risk score of serotonergic polymorphisms and social phobia: Interpersonal adaptability as a mediator.

Progress in neuro-psychopharmacology & biological psychiatry - 10 Jan 2025

Yang Yuting, Lan Qi, Liang Wenting, Zhou Mingzhu, Zhao Wenping, Gong Pingyuan

Abstract excerpt

BACKGROUNDS: The influence of serotonin function on social phobia has been well-documented, yet the polygenic risk score of serotonergic polymorphisms for social phobia remains unclear. METHODS: We assessed two aspects of social phobia (i.e., social interaction anxiety and social phobia scrutiny fear) and created a polygenic risk score of seven serotonergic polymorphisms in two independent samples. RESULTS: The...

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Identifiers

PMID: 39681252
DOI: 10.1016/j.pnpbp.2024.111220

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