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Article

Clinical scores fail to sufficiently identify children with familial hypercholesterolaemia.

European journal of preventive cardiology - 18 Feb 2026

Schmieder Raphael S, Krefting Johannes, Ates Sara, Schlieben Lea Dewi, Arens Stefan, Kordonouri Olga, Sander Michaela, Holdenrieder Stefan, Mall Volker, Meitinger Thomas, von Scheidt Moritz, Koenig Wolfgang, Leipold Georg, Prokisch Holger, Schunkert Heribert, Sanin Veronika

Abstract excerpt

AIMS: The study aimed to assess the effectiveness of three clinical diagnostic criteria [Simon Broome (SB), MEDPED (MP), and guideline-derived (GL-EAS)] in identifying children with familial hypercholesterolaemia (FH) compared with genetic testing. The evaluation involved 1337 children with elevated LDL cholesterol (LDL-C) levels, focusing on the sensitivity and specificity of these clinical scores in detecting...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40632909
DOI: 10.1093/eurjpc/zwaf301

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FH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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