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Article

Cellular Identification of Single-Base Mutations in KRAS Gene Fragments Based on Nonhomologous Spectroscopic Data Fusion Modeling.

Journal of biophotonics - 1 Oct 2025

Wang Chenchen, Abudureyimu Alimire, Zhang Qin, You Weiquan, Li Dandan, Jia Xiaofan, Zhang Yating, Chen Chengjie, Hu Rong, Wang Mengyao, Feng Shangyuan, Guo Pengfei, Chen Yang

Abstract excerpt

The sensitivity of KRAS gene mutation detection in colorectal cancer (CRC) can affect prognosis. This study established a nonhomologous spectroscopic data fusion method based on nuclear magnetic resonance (NMR) and laser tweezers Raman spectroscopy (LTRS), in order to analyze the metabolic characteristics of wild-type cells DKS-8 and HEK-3, and their respective mutant cells DLD-1 and HCT-116. Through multivariate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40629547
DOI: 10.1002/jbio.202500239

Genes

KRAS
DLD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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