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Article

Pan-cancer multi-omics profiling of MS4A2 unveils its functional landscape in lung adenocarcinoma.

International journal of surgery (London, England) - 1 Nov 2025

Zhang Bitian, Cho William Chi-Shing, Leung Ping-Chung, Wong Chun-Kwok, Wang Dongjie

Abstract excerpt

BACKGROUND: The membrane-spanning 4-domains subfamily A member 2 (MS4A2), a mast cell-specific IgE receptor component, exhibits paradoxical roles in cancer progression. While pan-cancer analyses suggest its context-dependent duality, its prognostic hierarchy across survival metrics - overall survival (OS), disease-specific survival (DSS), progression-free interval (PFI), and disease-free interval (DFI) - remains...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40607924
DOI: 10.1097/JS9.0000000000002903
PMCID: PMC12626506

Genes

MS4A2
CCL19
CCL20
CCL21
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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