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Article

NME4: A novel metabolic-associated biomarker for prognosis prediction and immunotherapy response evaluation in clear cell renal cell carcinoma.

Molecular immunology - 1 Aug 2025

Cheng Shilong, Lin Qisheng, Chen Kai, Wang Jiaxing, Peng Hangyang, Huang Yaqiang, Mao Xiangming, Lu Jianming, Zhong Chuanfan

Abstract excerpt

BACKGROUND: The incidence of renal cell carcinoma (RCC) remains high and continues to rise annually, with the clear cell subtype accounting for the majority of cases histologically. While immunotherapy has partially improved the 5-year relative survival rate, response rates vary due to individual heterogeneity, and the overall prognosis remains poor, particularly for high-stage patients. There is an urgent need...

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Source

Identifiers

PMID: 40602220
DOI: 10.1016/j.molimm.2025.06.011

Genes

NME4

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