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Article

Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

2 Jul 2025

Abstract excerpt

BACKGROUND: Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non-canonical Wnt signaling. RESULTS: , which serves as a prototype for other pathogenic variants. We show that epithelial imaginal disc...

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PMID: 40600289
DOI: 10.1002/dvdy.70056

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Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease modelPMID 40600289Read ↗

Robinow Syndrome <i>DVL1</i> variants disrupt morphogenesis and appendage formation in a Drosophila disease modelSemantic proximity Read ↗

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