Article

Robinow Syndrome <i>DVL1</i> variants disrupt morphogenesis and appendage formation in a Drosophila disease model

2024-09-10

Abstract excerpt

Robinow Syndrome is a rare developmental syndrome caused by variants in numerous genes involved in Wnt signaling pathways. We previously showed that expression of patient variants in Drosophila and a chicken model disrupts the balance of canonical and non-canonical/PCP Wnt signaling. We also noted neomorphic effects that warranted further investigation. In this study, we examine morphological changes that occur as...

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Literature Corpus work: ae3dc072-c19f-5eab-8aa4-4c82127d509f
DOI: 10.1101/2024.09.10.612347

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