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Diagnostic accuracy of urinary PENK methylation test for urothelial and other cancers: A prospective study

1 Jul 2025

Abstract excerpt

The methylated PENK gene is known to be highly expressed in the urine of patients with bladder cancer. Recent large-scale multicenter studies have confirmed the robust diagnostic performance of urinary PENK methylation, reporting high sensitivity and specificity for bladder cancer detection. However, its association with other cancers remains unclear. This prospective study aimed to determine the diagnostic...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 40596289
DOI: 10.1038/s41598-025-07173-5

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