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Clinical characteristics, disease evolution and survival in patients with chronic myeloid leukemia, BCR-ABL1 (+) and T315I mutation.

Folia medica - 31 Oct 2021

Goranova-Marinova Veselina, Linev Alexander, Ivanov Hristo J, Zheljazkov Ivan, Stoyanova Vily, Grudeva-Popova Zhanet

Abstract excerpt

INTRODUCTION: The T315I mutation in patients with chronic myeloid leukemia (CML) has been associated with therapeutic resistance and an unfavourable prognosis. AIM: To study the frequency of T315I mutation in patients with CML, BCR-ABL (+), their clinical characteristics, disease evolution, and median survival. PATIENTS AND METHODS: We studied 75 patients with CML and BCR-ABL1 (+). T315I mutation was detected by...

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Identifiers

PMID: 35851200
DOI: 10.3897/folmed.63.e63366

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