Deep Sequencing Reveals Dual Evolution of SARS-CoV-2: Insights Into Defective Genomes From Wuhan-Hu-1 Variants to Omicron Subvariants.

doi:10.1002/jmv.70476

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Deep Sequencing Reveals Dual Evolution of SARS-CoV-2: Insights Into Defective Genomes From Wuhan-Hu-1 Variants to Omicron Subvariants.

Journal of medical virology - 1 Jul 2025

Campos Carolina, Ibañez-Lligoña Marta, Colomer-Castell Sergi, Gregori Josep, Garcia-Cehic Damir, Andrés Cristina, Piñana Maria, González-Sánchez Alejandra, Rando-Segura Ariadna, Esperalba Juliana, Saubí Narcis, Cortese Maria Francesca, Tabernero David, Rodriguez-Frias Francisco, Ferrer Roser, Esteban Juan Ignacio, Kakze-van der Honing Renate W, Kampfraath Andries A, Vergara-Alert Júlia, Segalés Joaquim, van der Poel Wim H M, Pumarola Tomàs, Antón Andrés, Quer Josep

Abstract excerpt

SARS-CoV-2 has evolved from early variants dominating the first (B.1.5, B.1.1) and second (B.1.177) pandemic waves, which exhibited a higher frequency of minority mutants with deletions leading to Defective Viral Genomes (DVGs) in the spike region near the S1/S2 cleavage site than the Alpha, Beta, and Delta variants. The emergence of Omicron has significantly altered the dominant variant profile, with Omicron...

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PMID: 40586690
DOI: 10.1002/jmv.70476
PMCID: PMC12208013

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