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The frequency of defective genomes in Omicron differs from that of the Alpha, Beta and Delta variants

29 Dec 2022

Abstract excerpt

The SARS-CoV-2 Omicron variant emerged showing higher transmissibility and possibly higher resistance to current COVID-19 vaccines than other variants dominating the global pandemic. In March 2020 we performed a study in clinical samples, where we found that a portion of genomes in the SARS-CoV-2 viral population accumulated deletions immediately before the S1/S2 cleavage site (furin-like cleavage site, PRRAR/S)...

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PMID: 36581627
DOI: 10.1038/s41598-022-24918-8

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