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Article

Identification of novel drug targets for multiple sclerosis by integrating plasma genetics and proteomes.

Experimental gerontology - 1 Sept 2024

Liu Yi, Wang Qian, Zhao Yuhui, Liu Liu, Hu Jingxi, Qiao Yao, Chen Jinyi, Qin Chao

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have revealed numerous loci associated with multiple sclerosis (MS). However, the challenge lies in deciphering the mechanisms by which these loci influence the target traits. Here, we employed an integrative analytical pipeline to efficiently transform genetic associations to identify novel proteins for MS. METHODS: We systematically integrated MS GWAS data...

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PMID: 38964432
DOI: 10.1016/j.exger.2024.112505

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