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Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy

3 May 2023

Abstract excerpt

Circular RNAs (circRNAs) play important roles in the regulation of cancer. However, the clinical implications and regulatory networks of circRNAs in cancer patients receiving immune checkpoint blockades (ICB) have not been fully elucidated. Here, we characterize circRNA expression profiles in two independent cohorts of 157 ICB-treated advanced melanoma patients and reveal overall overexpression of circRNAs in ICB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37137884
DOI: 10.1038/s41467-023-38232-y

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