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Article

PTPRD pleiotropy, genetically driven childbirth timing, and corpus callosum microstructure as potential mechanisms underlying ADHD-RLS comorbidity.

Sleep medicine - 1 Sept 2025

Li Fu-Jia, Li Jin-Yu, Zhang Ru-Yu, Liu Xuan-Jing, Lv Bing-Chen, Zhang Tao, Liu Yu-Ning, Zhang Zi-Xuan, Zhang Wei, Cui Gui-Yun, Xu Chuan-Ying

Abstract excerpt

OBJECTIVES: To investigate the genetic mechanisms underlying the comorbidity of attention deficit hyperactivity disorder (ADHD) and restless legs syndrome (RLS). METHODS: We conducted a three-stage study to investigate the genetic relationship between ADHD and RLS. In the first stage, we used linkage disequilibrium score regression (LDSC) and high-definition likelihood (HDL) to assess genome-wide genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40561837
DOI: 10.1016/j.sleep.2025.106631

Genes

PTPRD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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