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Article

Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence.

JAMA psychiatry - 1 Sept 2025

Sun Kevin Y, Schmitt J Eric, Moore Tyler M, Barzilay Ran, Almasy Laura, Schultz Laura M, Mackey Allyson P, Kafadar Eren, Sha Zhiqiang, Seidlitz Jakob, Mallard Travis T, Cui Zaixu, Li Hongming, Fan Yong, Fair Damien A, Satterthwaite Theodore D, Keller Arielle S, Alexander-Bloch Aaron

Abstract excerpt

Importance: Functional brain networks are associated with both behavior and genetic factors. To uncover biological mechanisms of psychopathology, it is critical to define how the spatial organization of these networks relates to genetic risk during development. Objective: To determine the associations among transdiagnostic polygenic risk scores (PRSs), personalized functional brain networks (PFNs), and overall...

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Identifiers

PMID: 40560555
DOI: 10.1001/jamapsychiatry.2025.1258
PMCID: PMC12199186

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F2

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