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Article

Prognostic Features of Pediatric Primary Hemophagocytic Lymphohistiocytosis With CNS Involvement.

Journal of pediatric hematology/oncology - 1 Aug 2025

Zhao Chenzi, Zhang Qing, Jia Haoyue, Chen Sitong, Zhang Liping, Zhang Rui, Li Zhigang

Abstract excerpt

In this study, we analyzed genetic variation and prognostic factors in pediatric primary hemophagocytic lymphohistiocytosis (pHLH) with central nervous system (CNS) involvement, based on data from patients treated at Beijing Children's Hospital between September 2017 and September 2022. A total of 67 pHLH patients were included, with a median age of 4.3 years. Our findings revealed distinct genetic mutation...

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Identifiers

PMID: 40549926
DOI: 10.1097/MPH.0000000000003071

Genes

PRF1
EFS
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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