Bipolar disorder comorbidity in breast cancer: impact of genetic risk and lifestyle characteristic on breast cancer outcomes.

doi:10.1016/j.psychres.2025.116598

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Article

Bipolar disorder comorbidity in breast cancer: impact of genetic risk and lifestyle characteristic on breast cancer outcomes.

Psychiatry research - 1 Sept 2025

Ercis Mete, Solares-Bravo Melissa, Pazdernik Vanessa K, González-Campos Tamahara, Sanchez-Ruiz Jorge A, Ceylan Deniz, Larson Nicole L, Ruddy Kathryn J, Couch Fergus J, Olson Janet E, Frye Mark A, Winham Stacey J, Ozerdem Aysegul

Abstract excerpt

BACKGROUND: Bipolar disorder (BD) is associated with increased risk of breast cancer (BC), yet its impact on BC features and outcomes is unclear. We compared BC-Only patients and those with BD comorbidity (BC+BD) regarding BC characteristics and investigated associations between polygenic risk for BD (PRS-BD), a score based on common genetic variants, and BC outcomes. METHODS: Female patients from the Mayo Clinic...

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Topics

Humans
Female
Breast Neoplasms
Bipolar Disorder
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Comorbidity

Life Style

Adult

Longitudinal Studies

Registries

Aged

Genetic Predisposition to Disease

Multifactorial Inheritance

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 40541042
DOI: 10.1016/j.psychres.2025.116598

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