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Article

Influence of multi-species data on gene-disease associations in substance use disorder using random walk with restart models.

PloS one - 1 Jan 2025

Castaneda Everest U, Moore Sharon, Bubier Jason A, Grady Stephen K, Langston Michael A, Chesler Elissa J, Baker Erich J

Abstract excerpt

A major challenge lies in discovering, emphasizing, and characterizing human gene-disease and gene-gene associations. The limitations of data on the role of human gene products in substance use disorder (SUD) makes it challenging to transition from genetic associations to actionable insights. The integration of data from multiple diverse sources, including information-dense studies in model organisms, has the...

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PMID: 40522980
DOI: 10.1371/journal.pone.0325201
PMCID: PMC12169588

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