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Mechanistic Insights into PRRSV Inhibition through CD163–SRCR5 Blockade by PRRSV/CD163-IN-1

13 Jun 2025

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) causes severe economic losses in the swine industry by targeting pulmonary alveolar macrophages via the CD163 receptor, particularly its SRCR5 domain. However, the molecular details of small-molecule inhibition at this interface remain unclear. Here, we provide the first mechanistic insights into how the PRRSV/CD163-IN-1 (B7) compound blocks CD163–SRCR5....

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PMID: 40512485
DOI: 10.1021/acs.jpclett.5c01528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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