Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GP2a I118 and GP4 D43 play critical roles in the attachment of PRRSV to the CD163 receptor: implications for anti-PRRSV infection targets.

Journal of virology - 23 Sept 2025

Liu Guoqing, Huang Xinyi, Yang Yongbo, Chen Meng, Tian Xiaoxiao, Song Hao, Wang Haojie, Wang Shujie, Wang Haiwei, Cai Xuehui, An Tongqing

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) poses a significant threat to the global swine industry. Numerous modified live vaccines (MLVs) against PRRSV have been developed through the serial passage of wild-type parental strains in Marc-145 cells. However, the infectivity of these MLVs toward their primary target cell in vivo, porcine alveolar macrophage (PAM), is markedly reduced. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation, Myelomonocytic
Share to CD163 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages, Alveolar

Share to Porcine Reproductive and Respiratory Syndrome

Share to Porcine respiratory and reproductive syndrome virus

Share to Receptors, Virus

Share to Viral Tropism

Share to Virus Attachment

Source

Open in PubMed Open full text

Identifiers

PMID: 40823990
DOI: 10.1128/jvi.00963-25
PMCID: PMC12456131

Genes

PAM
CD163

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GP2a I118 and GP4 D43 play critical roles in the attachment of PRRSV to the CD163 receptor: implications for anti-PRRSV infection targets.PMID 40823990Read ↗

The GP2a 91/97/98 amino acid substitutions play critical roles in determining PRRSV tropism and infectivity but do not affect immune responsesSemantic proximity Read ↗

Challenges for Porcine Reproductive and Respiratory Syndrome (PRRS) Vaccine Design: Reviewing Virus Glycoprotein Interactions with CD163 and Targets of Virus NeutralizationSemantic proximity Read ↗

Structural comparison of CD163 SRCR5 from different species sheds some light on its involvement in porcine reproductive and respiratory syndrome virus-2 infection in vitro.Semantic proximity Read ↗

The Significance of the 98th Amino Acid in GP2a for Porcine Reproductive and Respiratory Syndrome Virus Adaptation in Marc-145 Cells.Semantic proximity Read ↗

Mutations within scavenger receptor cysteine-rich (SRCR) protein domain 5 of porcine CD163 involved in infection with porcine reproductive and respiratory syndrome virus (PRRS).Semantic proximity Read ↗

A Triple Amino Acid Substitution at Position 88/94/95 in Glycoprotein GP2a of Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV1) Is Responsible for Adaptation to MARC-145 CellsSemantic proximity Read ↗

Role of CD163 in PRRSV infectionSemantic proximity Read ↗

Porcine alveolar macrophage CD163 abundance is a pivotal switch for porcine reproductive and respiratory syndrome virus infectionSemantic proximity Read ↗

The Minor Envelope Glycoproteins GP2a and GP4 of Porcine Reproductive and Respiratory Syndrome Virus Interact with the Receptor CD163Semantic proximity Read ↗

PRRS virus receptors and an alternative pathway for viral invasionSemantic proximity Read ↗

Pig macrophages with site-specific edited CD163 decrease the susceptibility to infection with porcine reproductive and respiratory syndrome virusSemantic proximity Read ↗

The Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain of Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.