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Article

Reduced cell-substrate adhesion formation promotes cell migration in Dictyostelium.

Molecular biology of the cell - 1 Aug 2025

Fierro Morales Julio C, A Nguyen Thu, Nepal Sabin, Redfearn Chandler, Gale Bruce K, Titus Margaret A, Roh-Johnson Minna

Abstract excerpt

Many cells adhere to the extracellular matrix (ECM) for efficient cell migration. This adhesion is mediated by focal adhesions, a protein complex linking the ECM to the intracellular cytoskeleton. Focal adhesions have been studied extensively in metazoan mesenchymal cells, but recent research in physiological contexts and amoeboid cells suggests that focal adhesion regulation differs from the mesenchymal focal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40498666
DOI: 10.1091/mbc.E25-05-0230
PMCID: PMC12367306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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