Deciphering mitochondrial dysfunction in keratoconus: Insights into ACSL4 from machine learning-based bulk and single-cell transcriptome analyses and experimental validation

Abstract excerpt

Keratoconus (KC) is a prevalent ectatic corneal disease and the leading cause of corneal transplantation globally. Despite evidence of mitochondrial abnormalities in KC, the underlying mechanisms remain unclear. Our aim was to investigate the role of mitochondrial dysfunction in this pathological condition. Based on transcriptomics datasets of KC, mitochondria-related differentially expressed genes (mDEGs) were...

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