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High Gene Expression Predicts Extremely Low Segregation of Deleterious Mutations in Large Penguin Populations.

Molecular biology and evolution - 4 Jun 2025

Trucchi Emiliano, Massa Piergiorgio, Giannelli Francesco, Latrille Thibault, Gargano Marco, Nitta Fernandes Flavia A, Ancona Lorena, Stenseth Nils Chr, Ferrer Obiol Joan, Paris Josephine, Bertorelle Giorgio, Le Bohec Céline

Abstract excerpt

Purifying selection is the most pervasive type of selection, as it constantly removes deleterious mutations arising in populations, directly scaling with population size. Highly expressed genes appear to accumulate fewer nonsynonymous mutations between divergent species' lineages (known as E-R anticorrelation), pointing toward gene expression as an additional component modulating the selection coefficient of...

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PMID: 40493494
DOI: 10.1093/molbev/msaf146
PMCID: PMC12199756

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