Article
Species-wide gene editing of a flowering regulator reveals hidden phenotypic variation.
PLoS biology - 1 Jun 2025
Lutz Ulrich, Bezrukov Ilja, Schwab Rebecca, Yuan Wei, Kollmar Marius, Weigel Detlef
Abstract excerpt
Genes do not act in isolation, and the effects of a specific variant at one locus can often be greatly modified by polymorphic variants at other loci. A good example is FLOWERING LOCUS C (FLC), which has been inferred to explain much of the flowering time variation in Arabidopsis thaliana. We use a set of 62 flc species-wide mutants to document pleiotropic, genotype-dependent effects for FLC on flowering as well...
Read the complete abstract on PubMedTopics
- Gene Editing
- Gene Expression Regulation, Plant
- Gene Expression
- Flowers
- MADS Domain Proteins
- Mutation
