Spliceosome buffers cryptic genetic variation to enforce phenotypic robustness in Arabidopsis.

Abstract excerpt

Cryptic genetic variations (CGVs), which are phenotypically silent under normal conditions, can compromise phenotypic robustness when unmasked. Canalization buffers CGV to stabilize phenotypes, yet the underlying molecular mechanisms remain largely unknown. Here, we show that alternative splicing acts as a canalization mechanism in Arabidopsis. A natural single-nucleotide polymorphism in the functionally unknown...

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