Article
Cryptic variation fuels plant phenotypic change through hierarchical epistasis.
Nature - 1 Aug 2025
Zebell Sophia G, Martí-Gómez Carlos, Fitzgerald Blaine, Cunha Camila P, Lach Michael, Seman Brooke M, Hendelman Anat, Sretenovic Simon, Qi Yiping, Bartlett Madelaine, Eshed Yuval, McCandlish David M, Lippman Zachary B
Abstract excerpt
Cryptic genetic variants exert minimal phenotypic effects alone but are hypothesized to form a vast reservoir of genetic diversity driving trait evolvability through epistatic interactions1-3. This classical theory has been reinvigorated by pan-genomics, which is revealing pervasive variation within gene families, cis-regulatory regions and regulatory networks4-6. Testing the ability of cryptic variation to fuel...
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