Neuropathological examination of 12 cases of familial Parkinson’s disease with LRRK2 I2020T mutation including tau and TDP-43 pathology

Abstract excerpt

We previously reported a clinicopathological examination in the Sagamihara family, familial PD with LRRK I2020T mutation, highlighting the most common neuropathological finding as pure nigral degeneration without Lewy bodies (LBs). We applied immunohistochemical analysis to seven previously reported cases and evaluated five additional cases for a full neuropathological examination (altogether 12 cases). All cases...

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