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Article

Choice architecture in cascade genetic testing (CHARGE study) for hereditary cancer: Design of a hybrid type I randomized feasibility trial.

Contemporary clinical trials - 1 Aug 2025

Makhnoon Sukh, Getchell Grace, Rodriguez Yanete, Pena Luis, Rodriguez Jennifer, Ibidapo Tiwatope, Henrikson Nora B, Lee MinJae, Wu Shelly, Pirzadeh-Miller Sara

Abstract excerpt

BACKGROUND: Although cascade testing affords disease-free relatives the opportunity for genetically targeted primary disease prevention and is endorsed by multiple guidelines, utilization studies reveal that rates remain low. Lack of family communication and high testing costs are two of the most commonly documented barriers to testing. We leverage two well-known choice-architecture tools from psychology and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40482962
DOI: 10.1016/j.cct.2025.107979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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