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Article

A DDX31/Mutant-p53/EGFR Axis Promotes Multistep Progression of Muscle-Invasive Bladder Cancer.

Cancer research - 1 May 2018

Daizumoto Kei, Yoshimaru Tetsuro, Matsushita Yosuke, Fukawa Tomoya, Uehara Hisanori, Ono Masaya, Komatsu Masato, Kanayama Hiro-Omi, Katagiri Toyomasa

Abstract excerpt

The p53 and EGFR pathways are frequently altered in bladder cancer, yet their contributions to its progression remain elusive. Here we report that DEAD box polypeptide 31 (DDX31) plays a critical role in the multistep progression of muscle-invasive bladder cancer (MIBC) through its sequential interactions with mutant p53 (mutp53) and EGFR. In early MIBC cells, nuclear DDX31-bound mutp53/SP1 enhanced mutp53...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29440146
DOI: 10.1158/0008-5472.CAN-17-2528

Genes

DDX31
EGFR
NCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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