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Article

Recombinase polymerase amplification for single nucleotide polymorphism-specific detection of βC variant in sickle cell disease.

Analytical biochemistry - 1 Oct 2025

Jahangir Mehnaz Urbee, Chang Megan M, Wilkinson Alexis, Wazir Zoha, Tubman Venée N, Airewele Gladstone E, Richards-Kortum Rebecca

Abstract excerpt

Sickle cell disease (SCD) comprises a group of inherited blood disorders caused by point mutations in the β-globin gene. SCD is characterized by at least one βS globin allele and a second pathologic globin variant that results in predominant formation of hemoglobin S (HbS). Early diagnosis in low-and middle-income countries is limited by the high cost and complexity of DNA-based tests. Recombinase Polymerase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40460986
DOI: 10.1016/j.ab.2025.115919
PMCID: PMC13135376

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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