CleanSeqU algorithm for decontamination of catheterized urine 16S rRNA sequencing data

Abstract excerpt

Contamination in low-biomass samples, such as urine, presents a major challenge for 16S rRNA gene sequencing, as extraneous DNA from reagents and the environment often obscures microbial signals. Existing in silico decontamination algorithms face limitations in accurately identifying and removing these contaminants. To address this issue, we developed CleanSeqU, a novel decontamination algorithm designed to...

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