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Elevated HIF-1α as a diagnostic biomarker in COPD: Correlations with EPO, emphysema index, and pulmonary function.

Respiratory medicine - 1 Jan 2025

Atalay Nurettin Andac, Yormaz Burcu, Şahin Ali, Sonmez Gamze, Colkesen Sinem Suphan, Vatansev Husamettin, Ozer Halil, Korez Muslu Kazim

Abstract excerpt

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with phenotypes including chronic bronchitis and emphysema. Hypoxia-inducible factor-1 alpha (HIF-1α) mediates cellular responses to hypoxia, while vascular endothelial growth factor (VEGF) promotes angiogenesis and erythropoietin (EPO) serves as a hypoxia-activated hematopoietic growth factor. OBJECTIVES: To determine the...

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PMID: 40446862
DOI: 10.1016/j.rmed.2025.108184

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EPO

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