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Article

An integrative approach to prioritize candidate causal genes for complex traits in cattle.

PLoS genetics - 1 May 2025

Ghoreishifar Mohammad, Macleod Iona M, Chamberlain Amanda J, Liu Zhiqian, Lopdell Thomas J, Littlejohn Mathew D, Xiang Ruidong, Pryce Jennie E, Goddard Michael E

Abstract excerpt

Genome-wide association studies (GWAS) have identified many quantitative trait loci (QTL) associated with complex traits, predominantly in non-coding regions, posing challenges in pinpointing the causal variants and their target genes. Three types of evidence can help identify the gene through which QTL acts: (1) proximity to the most significant GWAS variant, (2) correlation of gene expression with the trait,...

Read the complete abstract on PubMed

Topics

Animals
Cattle
Quantitative Trait Loci
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Milk

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Female

Transcriptome

Multifactorial Inheritance

Source

Open in PubMed Open full text

Identifiers

PMID: 40446200
DOI: 10.1371/journal.pgen.1011492
PMCID: PMC12158001

Genes

ABHD3
ACSM5
ARV1
CYP2U1
DGAT1
NPC2
PIGL
SERINC5

Provenance

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