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Article

The nitrofen/bisdiamine murine model of congenital diaphragmatic hernia has a pulmonary hypertension vascular phenotype consistent with human CDH.

American journal of physiology. Lung cellular and molecular physiology - 1 Jul 2025

Gonyea Cailin R, Shen Yuanjun, Nelson Katherine M, Bird Rylie N, Gilbert Rachel M, Olutoye Oluyinka O, Keswani Sundeep G, Gleghorn Jason P

Abstract excerpt

Congenital diaphragmatic hernia (CDH)-associated pulmonary hypertension (CDH-PH) has severe implications for the survival of patients with CDH; however, CDH-PH is often refractory to pulmonary vasodilators, rendering it difficult to treat. As such, models are necessary to study the etiology, mechanism, onset, and progression of pulmonary vascular remodeling in CDH. Despite several established murine models of...

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Share to Disease Models, Animal
Share to Hernias, Diaphragmatic, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

Share to Mice, Inbred C57BL

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Share to Vascular Remodeling

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Identifiers

PMID: 40445713
DOI: 10.1152/ajplung.00233.2024
PMCID: PMC12235656

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